Journal article
E. Grodin, L. Steckler, R. Momenan
Alcohol and alcoholism, 2016
Alcohol and alcoholism, 2016
Semantic Scholar
DOI
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APA
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Grodin, E., Steckler, L., & Momenan, R. (2016). Altered Striatal Response During Effort-Based Valuation and Motivation in Alcohol-Dependent Individuals. Alcohol and Alcoholism.
Chicago/Turabian
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Grodin, E., L. Steckler, and R. Momenan. “Altered Striatal Response During Effort-Based Valuation and Motivation in Alcohol-Dependent Individuals.” Alcohol and alcoholism (2016).
MLA
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Grodin, E., et al. “Altered Striatal Response During Effort-Based Valuation and Motivation in Alcohol-Dependent Individuals.” Alcohol and Alcoholism, 2016.
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@article{e2016a,
title = {Altered Striatal Response During Effort-Based Valuation and Motivation in Alcohol-Dependent Individuals.},
year = {2016},
journal = {Alcohol and alcoholism},
author = {Grodin, E. and Steckler, L. and Momenan, R.}
}
Abstract
AIMS To use functional magnetic resonance imaging (fMRI) to investigate the neural circuitry behind effort-related valuation and motivation in a population of alcohol-dependent participants and healthy controls.
METHODS Seventeen alcohol-dependent participants and a comparison group of 17 healthy control participants completed an effort-based motivation paradigm during an fMRI scan, in which they were required to exert effort at varying levels in order to earn a monetary reward.
RESULTS We found that alcohol-dependent participants were less motivated during trials requiring high levels of effort. The whole-brain fMRI analysis revealed that alcohol-dependent participants displayed an increased blood-oxygen-level dependent (BOLD) signal during low and unknown effort cues in the dorsal and ventral striatum compared with healthy controls.
CONCLUSION These findings provide the first evidence that alcohol-dependent participants and healthy controls differ in their effort-based valuation and motivation processing. Alcohol-dependent participants displayed a hyperactive mesolimbic reward circuitry recruited by non-drug rewards, potentially reflecting a sensitization to reward in this patient population.