Journal article
Steven J. Nieto, E. Grodin, Diana Ho, Wave-Ananda Baskerville, L. Ray
Alcoholism, clinical and experimental research, 2022
Alcoholism, clinical and experimental research, 2022
Semantic Scholar
DOI
PubMed
Cite
Cite
APA
Click to copy
Nieto, S. J., Grodin, E., Ho, D., Baskerville, W.-A., & Ray, L. (2022). Moderators of subjective response to alcohol in the human laboratory. Alcoholism, Clinical and Experimental Research.
Chicago/Turabian
Click to copy
Nieto, Steven J., E. Grodin, Diana Ho, Wave-Ananda Baskerville, and L. Ray. “Moderators of Subjective Response to Alcohol in the Human Laboratory.” Alcoholism, clinical and experimental research (2022).
MLA
Click to copy
Nieto, Steven J., et al. “Moderators of Subjective Response to Alcohol in the Human Laboratory.” Alcoholism, Clinical and Experimental Research, 2022.
BibTeX Click to copy
@article{steven2022a,
title = {Moderators of subjective response to alcohol in the human laboratory.},
year = {2022},
journal = {Alcoholism, clinical and experimental research},
author = {Nieto, Steven J. and Grodin, E. and Ho, Diana and Baskerville, Wave-Ananda and Ray, L.}
}
Abstract
BACKGROUND Subjective response (SR) to alcohol represents a biobehavioral risk factor for heavy drinking and for developing alcohol use disorder (AUD). Identifying moderators of SR has been hindered by small sample sizes that are often used in alcohol administration studies.
METHODS This study culled from multiple alcohol administration trials to test whether sex, family history of alcohol problems, and impulsivity (via delay discounting) predict SR to alcohol, comprised of four domains: stimulation, sedation, negative affect, and craving. Non-treatment-seeking heavy drinkers (N=250) completed a battery of self-report scales and behavioral measures of alcohol use and problems, mood, and impulsivity. All participants completed an intravenous alcohol administration session wherein SR domains were measured at baseline, 20, 40, and 60mg%.
RESULTS Analyses using multilevel modeling found that male sex independently predicted higher alcohol-induced stimulation and alcohol craving, after controlling for other moderators. Family history of alcohol problems independently predicted alcohol craving controlling for other moderators.
CONCLUSIONS Through a large sample and advanced data analytic methods, this study extends the literature by suggesting important moderators of SR in heavy drinkers, namely male sex and family history of alcohol problems. These findings consolidate and extend a growing body of research on who is most likely to report the SR features that confer risk for AUD.